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WhatsApp: +86 18838072829SS31 is a synthetic peptide that improves mitochondrial function and is currently undergoing clinical trials for treatments of heart failure, primary mitochondrial myopathy, and other mitochondrial diseases. SS31 interacts with cardiolipin which is abundant in the inner mitochondrial membrane, but mechanistic details of its pharmacological ...
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WhatsApp: +86 18838072829SS31 Confers Cerebral Protection by Reversing Mitochondrial Dysfunction in Early Brain Injury Following Subarachnoid Hemorrhage, via the Nrf2 and PGC1αDependent Pathways Neurochem Res. 2023 May;48 (5):. doi: /s. Epub 2022 Dec 27. Authors
WhatsApp: +86 18838072829SS31 is a cellpermeable mitochondriatargeted antioxidant peptide. Previous studies have demonstrated that SS31 selectively partitions to the inner mitochondrial membrane, where it scavenges ROS generated by the electron transport chain.
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WhatsApp: +86 18838072829Peaks with an elution time of min represent SS31. (B) The release profiles of SCTKSS31 and SCNOSS31 in the presence of 10 mM H 2 O 2 monitored by HPLC. The data are the means ± SD. n = 3.
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WhatsApp: +86 18838072829Reprinted with permission from [131] SCTKSS31 was produced by conjugating SS31 to Lserinemodified chitosan (SC). Chitosan bound to heparin sulfate and glucosamine sulfate in the glomerulus via ...
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